Novel targets of pentacyclic triterpenoids in Staphylococcus aureus: a systematic review

Pentacyclic triterpenoids are based on a 30-carbon skeleton comprising five six-membered rings (alpha-amyrin), and four six-membered rings and one five-membered ring (betulinic acid and betulinaldehyde). Transcriptomic analyses revealed these three compounds regulate multiple desirable targets in cell division, two-component system, and the biosynthesis of fatty acid, peptidoglycan and aminoacyl-tRNA.Image, graphical abstract.