Abstract 107: IGF-1 Nanoparticles Improve Functional Recovery after Nerve Repair

RESULTS: Tissue oxygenation was negatively correlated with distance from the flap pedicle (r = -0.798) with a statistically significant decrease in mean tissue oxygenation in distal tissues (p < 0.001). Necrotic tissue on post-operative day seven demonstrated a significantly lower intra-operative tissue oxygenation (32.1%) compared to healthy tissue (58.6%, p < 0.001). As a predictor for tissue necrosis, intraoperative tissue oxygenation demonstrated an area under the ROC curve of 0.969. Control rats demonstrated more tissue necrosis than those receiving a single or two doses of topical nitroglycerin (51.3% vs. 28.8% vs 18.8%, respectively; p=0.035). Near-infrared spectroscopy demonstrated a significant increase in tissue oxygenation between the intra-operative and 24-hours post-operative timepoints in ischemic tissue receiving nitroglycerin (+17.8%, p<0.001).