Resveratrol ameliorates long-term structural, functional and metabolic perturbations in a rat model of donor nephrectomy: Implication of SIRT1

Marianne Basta,Abeer E. Dief,Doaa A. Ghareeb,Samar R. Saleh,Amany Elshorbagy,Eman El Eter

Journal of Functional Foods（2019）

引用 3|浏览16

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摘要

•UNX rats showed pathological changes in the remaining kidney and metabolic changes.•The remaining kidney showed decreased SIRT1 expression and elevated MDA levels.•Early resveratrol administration induced SIRT1 expression and decreased renal MDA.•Resveratrol protected the remaining kidney against damage, and dysmetabolism.

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关键词

Uninephrectomy,Resveratrol,SIRT1,Kidney donors,Chronic kidney disease

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