Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin-two cases.
Molecular genetics & genomic medicine(2019)
摘要
BACKGROUND:The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of patients with FXS demonstrated improvements in behavior.
METHODS:Here, we present two cases of individuals who have been treated with metformin clinically for one year.
RESULTS:Both patients demonstrated significant cognitive and behavioral improvements. They also improved eating habits and normalization of their weight percentiles.
CONCLUSION:Metformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS.
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关键词
cognition improvement,fragile X syndrome,metformin,targeted treatment
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