Effect of CREB1 promoter non-CpG island methylation on its differential expression profile on sheep ovaries associated with prolificacy.

Jie Zhao,Feng-Zhe Li, Jie Wu,Hua Yang,Jian Zheng,Jing Pang,Fan-Xing Meng,Feng Wang,Yan-Li Zhang

Tissue and Cell（2019）

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摘要

•CREB1 was expressed in granulosa cells and theca cells of mature follicles.•Methylation of DMR of promoter were increased in HP group than that in LP group.•The non-CGI methylation of CREB1 promoter may regulate gene expression on sheep ovaries.

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关键词

DNA methylation,Prolificacy,CREB1,Hu sheep

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