Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci.
EBioMedicine(2019)
摘要
Increased expression of BTN3A2 might confer risk for schizophrenia by altering excitatory synaptic function. Our result constitutes a paradigm for distilling risk gene using an integrative analysis and functional characterization in the post-GWAS era. FUND: This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020003 to Y-GY), the National Natural Science Foundation of China (31730037 to Y-GY), and the Bureau of Frontier Sciences and Education, Chinese Academy of Sciences (QYZDJ-SSW-SMC005 to Y-GY).
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关键词
Schizophrenia,Integrative analysis,BTN3A2,Brain development,Glutamatergic synapse
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