A new polyacetylene and other constituents with anti-inflammatory activity from Artemisia halodendron

A new polyacetylene, (3 R,8S)-heptadeca-1,16-dien-4,6-diyne-3,8-diol (1), together with 10 known compounds (2–11) were isolated from an ethanol extract of Artemisia halodendron Turcz. ex Bess. (Asteraceae). The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and by comparing these results with data reported in literatures. Compounds 1–11 were evaluated for their inhibitory activity against NO, TNF-α and IL-6 production. Compounds 1–11 significantly inhibited the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells in a dose-dependent manner, with IC50 values ranging from 15.12 to 66.97 µM.