Disassembly of Alzheimer's amyloid fibrils by functional upconversion nanoparticles under near-infrared light irradiation.

Zhimin Zhang,Jie Wang,Yongxiu Song,Zengkai Wang,Mingdong Dong,Lei Liu

Colloids and Surfaces B: Biointerfaces（2019）

引用 23|浏览7

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摘要

•We synthesized up-conversion nanomaterial β-NaYF4:Yb/Er@SiO2@RB.•UCNPs can generate reactive oxygen species(ROS) with noninvasive light irradiation.•UCNPs can convert the secondary-structure of peptide and degrade amyloid fibrils.

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关键词

Surface modification of nanomaterials,Amyloid β disassembly,Near infrared light irradiation,Up-conversion nanomaterials,Neurodegenerative disease

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