Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.

Yuan-Yuan Hei,San-Qi Zhang,Yifan Feng,Jin Wang,Weiming Duan,Hao Zhang,Shuai Mao,Haopeng Sun,Minhang Xin

Bioorganic & Medicinal Chemistry（2019）

引用 13|浏览11

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摘要

•Alkylsulfonamide-containing quinazoline derivatives was synthesized.•Compound A1 displayed potent inhibitory activity against the PI3K.•Compound A1 inhibited HCT-116, MCF-7 and SU-DHL-6 cells growth.•A1 markedly inhibit cancer growth in nude mouse HCT-116 xenograft model in vivo.

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关键词

Quinazoline,PI3K inhibitor,Drug design,Antiproliferative effects,Anticancer agent

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