154 – Gut Microbe-Produced Short Chain Fatty Acids Entrain Circadian Rhythms in Murine Enteroids by Histone Deacetylase Inhibition

Pentoxifylline Placebo group(n= P value group(n=45) 38) Development of any outcomes of moder-24 (53.3%) 15 (38.5%) 0.21 ate or severe CRP(day3-0), mean (SD), mg/L (n= 17.7 (121.0)23.1 (120.4)0.64 21,10) TNF-α(day3-0), mean (SD , pg/ml 0.2 (0.9) 0.2 (0.4) 0.97 (n=19,10) IL-6(day3-0), mean (SD) ,pg/ml (n= -81.1 (105.8)-19.6 (156.3)0.16 21,10) IL-8(day3-0), mean (SD) ,pg/m (n= -13.2 (22.4) -4.4 (14.4) 0.30 21,11)