Age Trajectory Of Deep White Matter Intensity In Bipolar Disorder Type-I Using Mri

Myelin development in the cortex follows an “inverted U” trajectory across the healthy lifespan, peaking in middle adulthood. This can be seen using myelin-sensitive magnetic resonance imaging (MRI) signals such as the T1-weighted/proton density-weighted (T1/PD) ratio. It has recently been shown that in Type-I bipolar disorder (BD) the T1/PD MRI signal in the cortex follows a significantly flattened age trajectory. In this study we investigate myelin development in the deep white matter in patients with BD by looking at the age trajectory of the T1/PD MRI signal.