Back Cover: Lactosamine‐Based Derivatives As Tools to Delineate the Biological Functions of Galectins: Application to Skin Tissue Repair (chembiochem 8/2017)

The back cover picture shows the collective keratinocyte migration that typically occurs during wound-healing. This highly efficient and complex process is driven by leader cells at the front of the cells, while the follower cells remain in close contact to move in concert. Galectin-3 is one of the key actors that control this fascinating example of cell–cell communication and multicellular organization. Blocking galectin-3 with small carbohydrate-based inhibitors, such as the one shown in blue, impairs the recruitment of actin (stained red by using rhodamine-coupled phalloidin) and results in the disorganization of actin fibers as well as that of podosomes, which are required for cell motility, and eventually leads to considerable delay in migration. More information can be found in the full paper by F. Poirier, C. Grandjean et al. on page 782 in Issue 8, 2017 (DOI: 10.1002/cbic.201600673).