T78. Attenuated Default Mode Network Functional Connectivity is Associated with Improvement in Depressive Symptoms Following Mindfulness-Based Cognitive Therapy in a Transdiagnostic Anhedonic Sample

Mindfulness-Based Cognitive Therapy (MBCT) is an effective intervention for improving depressive symptoms, but the neural mechanisms associated with treatment response are unclear. Mindfulness strategies promoted in MBCT involve psychological processes supported by the Default Mode Network (DMN) such as present-moment awareness and non-judgmental acceptance. Furthermore, DMN hyperconnectivity has been associated with both global depressive symptoms and with anhedonia specifically. Functional magnetic resonance imaging (fMRI) has not yet been reported to assess changes in DMN connectivity following MBCT in a clinically significant mood-impaired sample.