Nodulisporic Acid E Biosynthesis: In Vivo Characterisation Of Nodd1, An Indole-Diterpene Prenyltransferase That Acts On An Emindole Sb Derived Indole-Diterpene Scaffold

Kyle C. Van De Bittner,Rosannah C. Cameron,Leyla Y. Bustamante,Rudranuj Bundela,Sarah A. Kessans, Jan Vorster,Matthew J. Nicholson,Emily J. Parker

MEDCHEMCOMM（2019）

引用 7|浏览15

暂无评分

摘要

Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要