Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant.

Megumi Funakoshi-Tago,Rina Tsuruya,Fumihito Ueda, Aki Ishihara,Tadashi Kasahara,Hiroomi Tamura,Kenji Tago

Cytokine（2019）

引用 2|浏览11

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摘要

•SOCS3 induces the degradation of the JAK2 V617F mutant.•SOCS3 inhibits tumorigenesis induced by the JAK2 V617F mutant.•The phosphorylation of SOCS3 may be essential for its inhibitory effects.

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关键词

JAK2 V617F mutant,Myeloproliferative neoplasms (MPNs),SOCS3,SH2 domain,Phosphorylation

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