Repeated mild traumatic brain injury induces persistent variations in mitochondrial DNA copy number in mesocorticolimbic neurocircuitry of the rat.

Nagalakshmi Balasubramanian, Abhinav Srivastava,Namrata Pawar,Sneha Sagarkar,Amul J Sakharkar

Neuroscience Research（2020）

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摘要

•Mitochondrial DNA copy number (mtDNAcn) varied in different brain regions.•Repeated mild traumatic brain injury (rMTBI) induced persistent changes in mtDNAcn.•The 16S rRNA levels were concomitantly changed with respect to mtDNAcn variations.

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关键词

AMY,BNST,CTX,GAPDH,HP,HPRT,HT,MCL,mtDNAcn,NAc,PFC,PGC-1α,PTSD,RG,rMTBI,TBI,VTA

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