Piperine Modulates Protein Mediated Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome through Interacting Expanded CGG Repeat (r(CGG) exp ) RNA

Arun Kumar Verma
Arun Kumar Verma
Eshan Khan
Eshan Khan
Subodh Kumar Mishra
Subodh Kumar Mishra
Neha Jain
Neha Jain

ACS chemical neuroscience, Volume 10, Issue 8, 2019, Pages 3778-3788.

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Keywords:
FXTASNeurodegenerative diseasesfragile X-associated tremor/ataxia syndromeprotein mediated cytotoxicityr(CGG) RNAMore(2+)

Abstract:

An expansion of CGG tandem repeats in the 5' untranslated region (5'-UTR) of fragile X mental retardation 1 ( FMR1) gene causes fragile X-associated tremor/ataxia syndrome (FXTAS). The transcripts of these expanded repeats r(CGG) either form RNA foci or undergo the repeat-associated non-ATG (RAN) translation that produces toxic homopolyme...More

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