Piperine Modulates Protein Mediated Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome through Interacting Expanded CGG Repeat (r(CGG) exp ) RNA
ACS chemical neuroscience, Volume 10, Issue 8, 2019, Pages 3778-3788.
FXTASNeurodegenerative diseasesfragile X-associated tremor/ataxia syndromeprotein mediated cytotoxicityr(CGG) RNAMore(2+)
An expansion of CGG tandem repeats in the 5' untranslated region (5'-UTR) of fragile X mental retardation 1 ( FMR1) gene causes fragile X-associated tremor/ataxia syndrome (FXTAS). The transcripts of these expanded repeats r(CGG) either form RNA foci or undergo the repeat-associated non-ATG (RAN) translation that produces toxic homopolyme...More
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