TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice.

Suling Huang,Shanyao Ma,Mengmeng Ning,Wenji Yang,Yangliang Ye,Lina Zhang,Jianhua Shen,Ying Leng

Metabolism（2019）

引用 29|浏览35

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摘要

•MN6 potently activated TGR5 and stimulated GLP-1 secretion.•MN6 improved glucose homeostasis in ob/ob and DIO mice.•MN6 enhanced insulin-stimulated glucose uptake in skeletal muscles of DIO mice.•MN6 prevented palmitate-induced insulin resistance in C2C12 myotubes.•MN6 ameliorated palmitate-induced insulin resistance by TGR5/cAMP/PKA pathway.

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关键词

AC,cAMP,DIO,DPP-4,EDL,FXR,GLP-1,HFD,ITT,LCA,OGTT,PKA,TGR5,UCP1

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