Study on diagnostic value of P1NP and beta-CTX in bone metastasis of patients with breast cancer and the correlation between them

OBJECTIVE: This study aimed to investigate the diagnostic value of the total amino-terminal propeptide of type 1 procollagen (P1NP) and C-terminal telopeptide of beta-I collagen (beta-CTX) in bone metastasis of patients with breast cancer and the correlation between them. PATIENTS AND METHODS: The medical records of 73 patients were retrospectively analyzed. These patients with breast cancer were treated in Oncology, General Surgery. and Orthopedic Departments in The Third People's Hospital of Qingdao from March 2014 to April 2017. including 40 patients with bone metastasis (bone metastasis group) and 33 patients with no bone metastasis (non-bone metastasis group). Other 40 healthy people who received physical examination in the same period were selected as the control group. The expression of P1NP and beta-CTX in plasma were detected by the Enzyme-linked immunosorbent assay, and the correlation between them was analyzed. RESULTS: There were significant differences in P1NP and beta-CTX concentrations among the three groups (p<0.05). The concentrations of P1NP in the control group and the non-bone metastasis group were significantly lower than that in the bone metastasis group (p<0.05); the concentrations of beta-CTX in the control group and the non-bone metastasis group were significantly lower than that in the bone metastasis group (p<0.05). P1NP: AUC=0.852. sensitivity: 72.5%, specificity: 93.9%, CUT OFF=66.44. beta-CTX: AUC=0.883. sensitivity: 85.0%, specificity: 84.8%. CUT OFF-69.8. Joint detection: AUC=0.952, sensitivity: 84.8%, specificity: 99.5%, CUT OFF-99.5. The results of the concentrations of P1NP and beta-CTX in the bone metastasis group detected by the Pearson correlation analysis showed that their concentrations were positively correlated in the bone metastasis group (r=0.764, p<0.05). CONCLUSIONS: P1NP and beta-CTX in plasma have a high diagnostic value for bone metastasis of breast cancer and have important significance in the diagnosis of bone metastasis and disease monitoring.