A novel LGI1 missense mutation causes dysfunction in cortical neuronal migration and seizures.
Brain Research(2019)
摘要
•Most epileptogenic genes are related to ion channels, but there are some exceptions.•A new LGI1 mutation can inhibit the radiation migration of cortical neurons.•Voxel analysis reveals a subtle structural abnormality in the proband.•The pathogenesis of some hereditary epilepsy may have a structural basis.
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关键词
Epilepsy,LGI1,Mutation,Neuronal migration
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