A Single-Cell Transcriptional Analysis Of Tumour Cells And The Immune Microenvironment During Disease Evolution In A Transgenic Mouse Model Of Myeloma
BLOOD(2018)
摘要
Introduction: Multiple Myeloma (MM) is consistently preceded by pre-malignant asymptomatic monoclonal gammopathies (AMG). To date, our understanding of the pathogenesis of progression to MM remains incomplete. Genetic analyses of AMG cells compared to MM-derived plasma cells (PCs) have found few differences, suggesting that progression may be mediated in part by tumour-extrinsic mechanisms. To comprehensively examine the cellular and molecular complexities of MM pathogenesis, we performed an unbiased single cell RNA-sequencing (scRNA-seq) analysis of tumour cells as well as immune cells from the tumour microenvironment (TME) derived from transgenic mice transitioning from AMG to MM.
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关键词
tumour cells,immune microenvironment,transgenic mouse model,single-cell
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