Ofatumumab Is Active And Safe In Patients With Relapsed/Refractory Splenic Marginal Zone Lymphoma (Smzl): Results From The Interim Analysis Of An Italian Multicenter Phase 2 Study (More Trial)

INTRODUCTION: Splenic marginal-zone lymphoma (SMZL) is a rare disease for which treatment strategies are poorly defined due to the lack of prospective clinical trials and mostly rely on expert opinions. Results from single-center cohorts suggest that rituximab, the most widely available anti-CD20 monoclonal antibody (MoAb), can achieve long-term control of the disease without any need of combining chemotherapy. Ofatumumab is a fully humanised anti-CD20 MoAb and displays a favorable safety profile with lower incidence and milder infusion-related reactions (IRRs) when compared to rituximab. Given the significant efficacy observed in other relapsed/refractory (R/R) indolent lymphomas, we designed a multicenter phase 2 study in Italy to evaluate the activity and safety of ofatumumab monotherapy in patients with R/R SMZL, even after prior treatment with rituximab. Herein, we report preliminary results of a …