Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls.

We identified a group of 3 MDMs in pancreatic juice that identifies patients with pancreatic cancer with an AUROC value of 0.90, including patients with early-stage disease or advanced precancer. These DNA methylation patterns might be included in algorithms for early detection of pancreatic cancer, especially in high-risk cohorts. Further optimization and clinical studies are needed.