Carbazole scaffolds in cancer therapy: a review from 2012 to 2018.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY(2019)
摘要
For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products. Carbazoles have taken an important part in all the existing anti-cancer drugs because of their discovery from a large variety of organisms, including bacteria, fungi, plants, and animals. In this article, we specifically explored the literature from 2012 to 2018 on the anti-tumour activities reported to carbazole derivatives and we have critically collected the most significant data. The most described carbazole anti-tumour agents were classified according to their structure, starting from the tricyclic-carbazole motif to fused tetra-, penta-, hexa- and heptacyclic carbazoles. To date, three derivatives are available on the market and approved in cancer therapy.
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关键词
Carbazole,cancer,cytotoxicity,targeted therapy,enzyme inhibitors
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