Live cell measurements of interaction forces and binding kinetics between Discoidin domain receptor 1 and collagen I with atomic force microscopy.

Anwesha Sarkar,Anjum Sohail,Jiayin Dong,Marco Prunotto,Kazuhiko Shinki,Rafael Fridman,Peter M Hoffmann

Biochimica et Biophysica Acta (BBA) - General Subjects（2019）

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摘要

•Atomic force microscopy (AFM) can selectively interrogate specific cell surface receptors on live cells•AFM measures binding kinetics of ligands to cell surface receptors and receptor densities across multiple cell variants•Antibodies allow for isolating specific receptors to be measured by AFM at the single molecule level•Cell surface receptor densities measured by AFM correspond with measurements by other methods

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关键词

Atomic force microscopy,Discoidin domain receptors (DDRs),Collagen,Integrins,Ligand-cell receptor interactions,Cell surface receptors

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