Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss.

Qining Yang,Yongwei Zhou,Pengfei Cai,Weicong Fu,Jinhua Wang,Qiang Wei,Xiaofei Li

International Immunopharmacology（2019）

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摘要

•Up-regulated HIF-2α contributes to the Osteoarthritis development•HIF-2α induces primary cilia loss in OA through HIF2α/AURKA/ NEDD9 pathway•HIF-1α does not involve into the primary cilia regulation under hypoxia in OA

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关键词

HIF-2α,Hypoxia induced factor 2α,NEDD9,Aurora kinase A,Primary cilia,Osteoarthritis

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