Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization.

Haruhiko Murata, Romelda Omeir,Wei Tu,Lynda Lanning,Kathryn Phy,Gideon Foseh,Andrew M Lewis,Keith Peden

Vaccine: X（2019）

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摘要

•Tumorigenicity assays can be time-consuming and results can be equivocal.•Basement membrane extract (BME) is known to enhance tumorigenicity.•The tumorigenicity of Vero (≤p258) and ARPE-19 cells were not enhanced by BME.•BME enhanced the tumorigenicity of HeLa, 293, MDCK, and transformed Vero cells.•BME may be a useful reagent for characterizing vaccine cell substrates.

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关键词

Tumor,Tumorigenicity,Vero,Nude mouse,Basement membrane,Matrigel

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