Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice.

Petra C Fay,Houssam Attoui,Carrie Batten,Fauziah Mohd Jaafar,George P Lomonossoff,Janet M Daly,Peter P C Mertens

Vaccine: X（2019）

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摘要

•Neutralising antibodies after vaccination of mice with bluetongue VP2 proteins.•Protection in mice against bluetongue 4 or 8, after vaccination with VP2 proteins.•High level expression of native VP2 proteins of bluetongue 4 or 8, in tobacco plants.

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关键词

Bluetongue,BTV,Bluetongue virus,Neutralising antibodies,Subunit protein,VP2,Vaccine,Vaccination,IFNAR −/−

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