Rates of lobar atrophy in asymptomatic MAPT mutation carriers.

•The trajectory change of brain atrophy on longitudinal magnetic resonance imaging collected over 10 years was investigated in asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.•A sequential pattern of regional cortical atrophy rates involving the temporal lobe cortex early on, followed by the frontal and parietal lobe cortices in MAPT mutation carriers as they transition from asymptomatic stage to symptomatic stage, was described.•Our findings support the clinical utility of using longitudinal regional volumes for monitoring the neurodegenerative disease progression in MAPT mutation carriers starting from the asymptomatic stage.