A separation-based enzymomics assay for the discovery of altered peptide-metabolizing enzymatic activities in biosamples.
ANALYTICAL CHEMISTRY(2019)
摘要
We have developed a novel method to globally monitor the enzymatic activities of biological samples based on performing the global activity analysis on a proteome separated by native electrophoresis. The study of the alteration in peptide-metabolizing enzymatic activity in colorectal tumor specimens led us to the discovery of elevated thimet oligopeptidase activity, which contributed to the faster consumption of immune-stimulating peptide neurotensin.
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