Thermoresponsive in Situ Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing.

forming hydrogel has emerged as a promising wound dressing recently. As physically crosslinked hydrogels were normally unstable, most forming hydrogels were chemically crosslinked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from crosslinkers or the polymer matrix. Herein, we report a sprayable forming hydrogel composed of poly(N-isopropylacrylamide--n-butylacrylate) -poly(ethylene glycol)- poly(N-isopropylacrylamide--n-butylacrylate) (P(NIPAM--nBA)-PEG-P(NIPAM--nBA), which denoted PEP) copolymer and silver nanoparticles decorated reduced graphene oxide nanosheets (Ag@rGO, which denoted AG) in response to the skin temperature. This thermo-responsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing on wound, which is attributed to the inorganic/polymeric dual-network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant () of this PEP-AG hydrogel wound dressing are confirmed and , which could transparently promote the healing of a infectious skin defect.