Chimera States And Seizures In A Mouse Neuronal Model

Chimera states - the coexistence of synchrony and asynchrony in a nonlocally-coupled network of identical oscillators - are often used as a model framework for epileptic seizures. Here, we explore the dynamics of chimera states in a network of modified Iiindmarsh-Rose neurons, configured to reflect the graph of the mesoscale mouse connectome. Our model produces superficially epileptiform activity converging on persistent chimera states in a large region of a two-parameter space governing connections (a) between subcortices within a cortex and (b) between cortices. Our findings contribute to a growing body of literature suggesting mathematical models can qualitatively reproduce epileptic seizure dynamics.