Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles.

Anya C Jones,Denise Anderson,Sally Galbraith,Emmanuelle Fantino,Diana Gutierrez Cardenas,James F Read,Michael Serralha,Barbara J Holt,Deborah H Strickland,Peter D Sly,Anthony Bosco,Patrick G Holt

Journal of Allergy and Clinical Immunology（2019）

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摘要

Febrile lower respiratory infections trigger uniquely potent/complex immunoinflammatory responses in infants, which enhance both immune maturation and asthma development. Characterization of underlying fever-associated transcriptomic profiles may unmask previously hidden clues regarding mechanisms driving asthma initiation.

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