Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Anne-Pauline Bellanger,Ana Berceanu,Emeline Scherer,Yohan Desbrosses,Etienne Daguindau,Steffi Rocchi,Laurence Millon

EMERGING INFECTIOUS DISEASES（2019）

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摘要

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.

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Aspergillus fumigatus,CT,France,Rhizomucor,acute myeloid leukemia,antimicrobial resistance,aspergillosis,computed tomography,death,fungal co-infection,fungi,galactomannan antigen,graft-versus-host disease,hematopoietic stem-cell transplantation,immunocompromised patients,invasive fungal disease,isavuconazole,mucormycosis,qPCR,quantitative PCR,treatment failure

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