Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects.

•After ICH, neurons show features of ferroptosis in vitro, in vivo and in human.•Ferroptosis occurs in the acute phase of ICH.•Ferroptosis presents in perihematoma and distant brain areas of hematoma.•Fer-1 exerts neuroprotective effects in long-term, but not in short term.