Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells.
Brain Research Bulletin(2019)
摘要
•Propofol prevents oxidative stress and apoptosis of nerve cells.•Propofol inhibited apoptosis via regulating iron homeostasis.•Propofol can protect against nerve injury induced by iron overload through JAK/STAT3 signaling pathway.
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关键词
AD,PRO,DMT1,Fpn1,FtH,FtL,MDA,MMP,POCD,qRT-PCR,ROS,TfR1,TUNEL,FAC,IL-6,Cox2,JAK,STAT3
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