Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis.

Elien Gevaert,Tim Delemarre,Joyceline De Volder,Nan Zhang,Gabriele Holtappels,Natalie De Ruyck,Emma Persson,Ines Heyndrickx,Kenneth Verstraete,Helena Aegerter,Hans Nauwynck,Savvas N Savvides,Bart N Lambrecht,Claus Bachert

The Journal of allergy and clinical immunology（2019）

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摘要

Highly stable Charcot-Leyden crystals in nasal polyp tissue are deposited by eosinophils undergoing EETosis and actively promote an inflammatory response that sustains chronic neutrophilic inflammation.

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