Emergence of ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae in China.

Ping Zhang,Qiucheng Shi,Huangdu Hu, Bao Hong,Xueqing Wu,Xiaoxing Du,Murat Akova,Yunsong Yu

Clinical Microbiology and Infection（2020）

引用 113|浏览19

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摘要

Resistance against CAZ/AVI in CRKP emerged before clinical use of CAZ/AVI in China, although most of the CRKP isolates maintained the susceptibility. MBL production, bla point mutation and high KPC expression played an important role in CAZ/AVI resistance.

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关键词

blaKPC,Carbapenem-resistant Klebsiella pneumoniae,Ceftazidime/avibactam,Metallo-β-lactamase,Ω-loop

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