Expression pattern of co-inhibitory molecules on CMV-specific T-cells in lung transplant patients.

Vasiliki Bessa,Ming Sun, Maike Meier,Ye Zeng,Shilei Xu,Sebastian Dolff,Urte Sommerwerck,Johannes Korth,Christian Taube,Clemens Aigner,Markus Kamler,Andreas Kribben,Monika Lindemann,Oliver Witzke,Benjamin Wilde

Clinical Immunology（2019）

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摘要

•The expression of co-inhibitory molecules on CMV-specific T-cells is altered in patients after lung transplantation•BTLA expression was enhanced on CMV-specific T-cells of R+ patients with CMV reactivation versus no CMV reactivation•Co-inhibition of virus-specific T-cells may hamper immunological control of CMV

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关键词

Cytomegalovirus,Lung transplant,T-cells,BTLA,PD-1,Co-inhibitors

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