Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents
Organic Letters(2019)
摘要
New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal biotinylation. The resulting biotinylated RNA was enriched and verified with RT-qPCR. This powerful chemical approach provides new opportunities to identify and quantify A-to-I editing sites.
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关键词
rna,acrylonitrile,adenosine-to-inosine
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