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A Tailored Molecular Profiling Programme for Children with Cancer to Identify Clinically Actionable Genetic Alterations.

Sally L. George,Elisa Izquierdo,James Campbell,Eleni Koutroumanidou,Paula Proszek,Sabri Jamal,Deborah Hughes,Lina Yuan,Lynley V. Marshall,Fernando Carceller,Julia C. Chisholm,Sucheta Vaidya,Henry Mandeville,Paola Angelini,Ajla Wasti,Tomas Bexelius,Khin Thway,Susanne A. Gatz,Matthew Clarke,Bissan Al-Lazikani

European Journal of Cancer（2019）

Cited 41|Views58
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Abstract
•The hybrid-capture panel gives reliable results from as little as 50 ng of DNA extracted from formalin-fixed paraffin-embedded tissue.•A tailored sequencing approach identifies ≥1 genetic alteration in 70% of samples and potentially actionable genetic alterations in 51% of patients.•In paired samples, from different treatment time points, there were differences in the genetic alterations detected.
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Key words
Paediatric oncology,Clinical targeted sequencing,Personalised medicine,Circulating tumour DNA
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