A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation.
CHEMICAL COMMUNICATIONS(2019)
摘要
A new nucleus-localized singlet oxygen generator was designed and synthesized. Its capability to label nucleus-localized biomolecules through spatially-restricted oxidation under visible light was validated using fluorescence confocal microscopy. Western blot and RT-qPCR were performed to verify the desirable spatial resolution through enriching chromatin-associated RNAs and proteins.
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关键词
irradiation,rnas,proximity labelling,chromatin-associated
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