Up-regulation of TIMP-3 and RECK decrease the invasion and metastasis ability of colon cancer.

Jinmiao Wang,Yunshou Lin,Tao Jiang,Chao Gao,Duowei Wang,Xiaodong Wang, Ying Wei,Tong Liu,Liwei Zhu,Pengzhi Wang,Feng Qi

Arab Journal of Gastroenterology（2019）

引用 6|浏览43

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摘要

Up-regulation of TIMP-3 and RECK, by inhibiting miR-21 expression can decrease tumour invasion and metastasis ability in vitro and in vivo, and has potential as a possible target site in anti-tumour therapy. More effects in vivo have to be investigated in further research.

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关键词

CRC,miR-21,MMP,PTEN,DMEM,FBS,Plasmid miRZip-21 (pmiRZip),RPMI,Leti3,bp,EGFP,DMEM,HPF,ECM,PCR,TIMP-3,RECK,BMPR-II

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