Henipavirus-like particles induce a CD8 T cell response in C57BL/6 mice.

Eileen Stroh,Kerstin Fischer,Theresa Schwaiger,Lucie Sauerhering,Kati Franzke,Andrea Maisner,Martin H Groschup,Ulrike Blohm,Sandra Diederich

Veterinary Microbiology（2019）

引用 6|浏览25

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摘要

•VLPs induce antigen-specific CD8 T cell response in C57BL/6 mice.•VLPs induce neutralizing antibody response in both C57BL/6 and BALB/c mice.•NiV G, NiV F as well as HeV M, harbor CD8 T cell epitopes.•The combination of NiV G, NiV F and HeV M induces a stronger CD8 T cell response than single-protein VLPs.

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关键词

Nipah virus,CD8 T cell response,Virus-like particles,C57BL/6 mice,Th1 cytokines

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