Early stage endometrial cancer, CTNNB1 mutations and the relationship between lymphovascular space invasion and recurrence.

This study supports the importance of lymphovascular space invasion to identify women with significant risk for recurrence in initially low-risk, early-stage endometrial cancer. It also identifies CTNNB1 as a significant mutation in early-stage disease and while it may not represent a marker for recurrence its high prevalence in early stage disease could have relevance for both pathogenesis and early treatment.