Tc-99m PMT scintigraphy in the diagnosis of pediatric biliary atresia
Japanese Journal of Radiology(2019)
摘要
Purpose Hepatobiliary scintigraphy plays an important role in the differentiation of biliary atresia (BA) and non-BA. The usefulness of 99m Tc-iminodiacetic acid (IDA) derivatives in BA diagnosis is reported in several papers. In contrast, there are no comprehensive data on differentiating BA from non-BA using 99m Tc- N -pyridoxyl-5-methyl-tryptophan (PMT). Our objective was to evaluate the usefulness of 99m Tc-PMT scintigraphy in the diagnosis of BA. Materials and methods 52 infants who received 99m Tc-PMT scintigraphy for suspected BA were retrospectively evaluated. Preoperative cholangiograms or follow-ups were used as the gold standard for diagnosis of BA. We analyzed the utility of 99m Tc-PMT scintigraphy, various clinical and investigational parameters in the diagnosis of BA. Results The final diagnoses in this group were BA (67.3%) and non-BA (32.7%). 99m Tc-PMT scintigraphy, stool color change, total bilirubin, direct bilirubin, aspartate aminotransferase (AST) and γ-glutamyl transferase (γ-GTP) led to distinguishing between BA and non-BA in univariate analysis. Subsequent multivariate logistic regression analysis indicated that 99m Tc-PMT scintigraphy and γ-GTP were independent predictors of BA. The diagnostic accuracy of 99m Tc-PMT scintigraphy was 94.2%. Conclusions 99m Tc-PMT scintigraphy is more accurate in the diagnosis of BA than other conventional examinations. In addition, false positives of 99m Tc-PMT scintigraphy could be reduced by combining γ-GTP level monitoring.
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关键词
99mTc-N-Pyridoxyl-5-methyl-tryptophan (PMT),Biliary atresia (BA),γ-Glutamyl transferase (γ-GTP)
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