Predicting a Distal Outcome Variable from a Latent Growth Model: ML versus Bayesian Estimation

Latent growth models (LGMs) with a distal outcome allow researchers to assess longer-term patterns, and to detect the need to start a (preventive) treatment or intervention in an early stage. The aim of the current simulation study is to examine the performance of an LGM with a continuous distal outcome under maximum likelihood (ML) and Bayesian estimation with default and informative priors, under varying sample sizes, effect sizes and slope variance values. We conclude that caution is needed when predicting a distal outcome from an LGM when the: (1) sample size is small; and (2) amount of variation around the latent slope is small, even with a large sample size. We recommend against the use of ML and Bayesian estimation with Mplus default priors in these situations to avoid severely biased estimates. Recommendations for substantive researchers working with LGMs with distal outcomes are provided based on the simulation results.