AB1013 CHILDREN IN RISK OF LOW BONE MASS HAVE MORE THAN 2 RISK FACTORS

Background Low Bone Mass (LBM)/Infantile Osteoporosis (IOP) require an active evaluation for its diagnosis and prevention. Therefore, its incidence is unknown and could be undertreated. The systematic collection of risk factors associated with LBM/IOP could help identify the population at risk of presenting it Objectives To assess the prevalence and number of risk factors (RF) in the pediatric population at risk of developing LBM/IOP. Assess its influence on Bone Mineral Density Methods Demographic and clinical data were prospectively collected from patients from 2 to 20 years of age, who had at least one risk factor for LBM/IOP, among them: chronic diseases, treatment with immunosuppressants and/or corticosteroids and insufficient calcium intake. Calcemia, calciuria, and vitamin D were determined in blood samples, and whole body and lumbar DXA were performed. The calcium intake, the number of previous fractures and other RF were collected Results Data were collected from 103 patients, with an average age of 9’8 years, 52’4% women, and 80%Caucasians. Of these, 9 were preschoolers (2-3 years old), 33 schoolchildren (4-9y), 55 teenagers (10-17th) and 6 young people (18-20th) The most frequent diagnoses were: Malabsorption/Food allergies: 46.6%, JIA: 17.5%, Nephropathies: 17.8%, Hematological diseases: 6.8%, and Vasculitis and connective tissue diseases: 3.9% each The frequency of RFs can be observed inTable 1 The average dose of current corticoids was 0.21 mg/kg/day of prednisone with a total cumulative average dose of: 7 gr, with an exposure of 1 to 144 months 4’3% of the sample had an isolated RF, 38% had 2 RF, 31% 3, 15% 4, and 12% 5 or more 8’7% of the sample presented a LBM and 4.8% met criteria for Opi for vertebral fractures, 3 of them asymptomatic and discovered by morphometry In the multiple linear regression analysis: age, latin ethnicity, gender, and hypovitaminosis D were the main RFs related to lumbar BMD. Likewise, age, latin ethnicity and sedentary lifestyle were the RF related to the BMD of the whole body without head (BMDwbwh) In lumbar BMD, these 4 FR explained up to 85% of the BMD variation, where the age adds 0’032 per year gained, the male sex subtracts 0’061, the hypovitaminosis D sum 0’077 and the latin ethnicity subtracts 0’070 Up to a 90’8% variation of BMDwbwh is explained by these 3 RF: age adds 0’036 per year gained, sedentary life subtracts 0’084 and latin ethnicity subtracts 0’055. Conclusion The child population at risk of LBM/IOp associates 2 or more risk factors 8.7% of children with risk factors have LBM and 4.8% IOP The RFs related to changes in BMD are: age, sex, sedentary lifestyle and ethnicity. Hypovitaminosis D correlated positively with lumbar BMD Disclosure of Interests None declared