Abstract 17111: Defective Activation of Transcription Factor CREB in Circulating CD4+ T-cells Might Explain the Reduced Anti-inflammatory Activity in Patients with Acute Coronary Syndrome

Davide Flego,Anna Severino,Francesco Trotta,Marco Previtero,Ada F Giglio,Vincenzo A Galiffa,Daniela Pedicino,Luigi M Biasucci,Giovanna Liuzzo,Filippo Crea

Circulation（2012）

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摘要

Background. Recent studies have highlighted the importance of T-cell disregulation in acute coronary syndromes (ACS). Cyclic-AMP response element binding protein (CREB) is a crucial transcription f...

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关键词

Acute coronary syndromes, Immune system, Inflammation, Cell signaling, Leukocytes

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