Benzoazacrown Compound: A Highly Effective Chelator For Therapeutic Bismuth Radioisotopes

A new benzoazacrown ligand H(4)BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H(4)DOTA in biologically relevant and challenging media under in vivo conditions.